解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particu...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3367
更新日期:2016-05-27 00:00:00
abstract::Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanis...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3349
更新日期:2016-04-27 00:00:00
abstract::The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3323
更新日期:2016-04-01 00:00:00
abstract::Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the asso...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3321
更新日期:2016-03-01 00:00:00
abstract::Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3251
更新日期:2015-11-01 00:00:00
abstract::Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3250
更新日期:2015-11-01 00:00:00
abstract::Blocking mitotic progression has been proposed as an attractive therapeutic strategy to impair proliferation of tumour cells. However, how cells survive during prolonged mitotic arrest is not well understood. We show here that survival during mitotic arrest is affected by the special energetic requirements of mitotic ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3231
更新日期:2015-10-01 00:00:00
abstract::Robust mechanisms to control cell proliferation have evolved to maintain the integrity of organ architecture. Here, we investigated how two critical proliferative pathways, Myc and E2f, are integrated to control cell cycles in normal and Rb-deficient cells using a murine intestinal model. We show that Myc and E2f1-3 h...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3210
更新日期:2015-08-01 00:00:00
abstract::The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cel...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3195
更新日期:2015-08-01 00:00:00
abstract::Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubic...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3197
更新日期:2015-07-01 00:00:00
abstract::The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3179
更新日期:2015-07-01 00:00:00
abstract::The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-pr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3141
更新日期:2015-04-01 00:00:00
abstract::During cell division, many animal cells transform into a spherical shape and assemble a contractile ring composed of actin filaments and myosin motors at the equator to separate the cell body into two. Although actomyosin regulatory proteins are spatio-temporally controlled during cytokinesis, the direct contribution ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3142
更新日期:2015-04-01 00:00:00
abstract::YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3111
更新日期:2015-04-01 00:00:00
abstract::Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3109
更新日期:2015-03-01 00:00:00
abstract::Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recen...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3108
更新日期:2015-03-01 00:00:00
abstract::Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3091
更新日期:2015-02-01 00:00:00
abstract::Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the premetastatic niche, by secreting vesicles that carry high levels of the miR-122 microRNA. High miR-122 levels in the cir...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3094
更新日期:2015-02-01 00:00:00
abstract::Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating bot...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3086
更新日期:2015-01-01 00:00:00
abstract::The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3075
更新日期:2015-01-01 00:00:00
abstract::Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that slide misaligned chromoso...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3060
更新日期:2014-12-01 00:00:00
abstract::Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3070
更新日期:2014-12-01 00:00:00
abstract::Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3059
更新日期:2014-11-01 00:00:00
abstract::Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3042
更新日期:2014-10-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3021
更新日期:2014-09-01 00:00:00
abstract::Growing microtubule end regions recruit a variety of proteins collectively termed +TIPs, which confer local functions to the microtubule cytoskeleton. +TIPs form dynamic interaction networks whose behaviour depends on a number of potentially competitive and hierarchical interaction modes. The rules that determine whic...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2999
更新日期:2014-08-01 00:00:00
abstract::Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2985
更新日期:2014-07-01 00:00:00
abstract::Cadherin-containing cell-cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of c...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb2980
更新日期:2014-06-01 00:00:00
abstract::Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein d...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2939
更新日期:2014-05-01 00:00:00
abstract::The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2954
更新日期:2014-05-01 00:00:00
abstract::To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2918
更新日期:2014-03-01 00:00:00
abstract::RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb2895
更新日期:2014-01-01 00:00:00
abstract::In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2889
更新日期:2014-01-01 00:00:00
abstract::Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors that induce brown adipocyte commitment and energy expenditure would be a promising defence against adiposity. ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2867
更新日期:2013-12-01 00:00:00
abstract::Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cells must bypass. Here we show by whole-genome single-nucleotide bi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2879
更新日期:2013-12-01 00:00:00
abstract::The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. Here we report that ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2860
更新日期:2013-11-01 00:00:00
abstract::Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2834
更新日期:2013-09-01 00:00:00
abstract::Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated t...
journal_title:Nature cell biology
pub_type: 评论,新闻
doi:10.1038/ncb2817
更新日期:2013-08-01 00:00:00
abstract::Actin networks drive many essential cellular processes, including cell migration, cytokinesis and tissue morphogenesis. However, how cells organize and regulate dynamic actin networks that consist of long, unbranched actin filaments is only poorly understood. This study in mouse oocytes reveals that cells can use vesi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2802
更新日期:2013-08-01 00:00:00
abstract::Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) involves a marked reorganization of chromatin. To identify post-translational histone modifications that change in global abundance during this process, we have applied a quantitative mass-spectrometry-based approach. We found that iPSCs, compa...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2768
更新日期:2013-07-01 00:00:00